While ingesting a more well-balanced, reduced-calorie diet and exercising regularly are the cornerstones of weight reduction, certain medications can function as powerful adjuncts.

One such medication is phentermine — among the standard weight loss medications on earth.

It’s been proven successful for short-term weight loss when used along with a reduced-calorie diet program and exercise.

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But, using phentermine for weight reduction isn’t without dangers and side effects.

This report explains all you want to know about phentermine, such as its benefits, dosage, and possible side effects.

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What Is Phentermine?

Phentermine is a prescription weight loss medication.

The FDA had accepted it in 1959 for short term usage of around 12 weeks for individuals older than 16.

From the 1990s, phentermine was united together with other weight loss medications. This drug combination was commonly referred to as fen-phen.

After reports of significant heart problems from consumers, the FDA pulled another two drugs used in the treatment — fenfluramine and dexfenfluramine — in the marketplace.

Phentermine goes by the brand names Adipex-P, Lomaira, and Suprenza, or you’ll be able to locate it in conjunction with drugs for weight reduction, for example, Qsymia.

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It is a controlled substance because of its chemical similarities to the stimulant amphetamine — which makes it available only with a prescription.

Your physician can prescribe phentermine if you are obese, meaning your body mass index (BMI) is higher than or equal to 30.

It might also be prescribed if you are overweight with a BMI higher than or equal to 27 and also have a minimum of one weight-related illness, such as hypertension, more elevated cholesterol, or form two diabetes.


Phentermine is an FDA-approved medication meant for weight reduction. Its chemical structure is very similar to amphetamine, and it is only available with a prescription.

How Does It Work?

Phentermine is a member of a category of medications known as”anorectics,” also called appetite suppressants.

Taking phentermine helps curb your appetite, thus restricting the number of calories you consume. With time, this may cause weight reduction.

While the specific mechanisms behind the appetite-reducing effects of phentermine stay unclear, the medication is supposed to act by increasing neurotransmitter levels in mind.

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When your levels of these three compounds increase, your sense of appetite dopamine.

But you might construct a tolerance to the appetite-suppressing effects of phentermine in a couple of weeks. If that’s the scenario, you shouldn’t raise your dose of this medication but quit using it entirely.


Phentermine is considered to reduce your hunger by increasing neurotransmitter levels in mind.

Effective for Weight Loss

Several clinical studies have shown that phentermine may boost weight reduction.

The anticipated average weight loss with phentermine usage is 5 percent of your initial body weight. However, over 12 weeks, it is often as large as 10 percent.

While phentermine was proven to work for weight reduction, it might work better when coupled with topiramate.

Topiramate is a medication that’s been used on its ability to take care of migraines, however — such as phentermine — has appetite-reducing properties.

In comparison to 3 other commonly prescribed medication for weight reduction, the combination of phentermine and topiramate was correlated with the highest likelihood of losing 5% of the initial body fat.

What is more, study suggests that the phentermine and topiramate blend is the Best weight loss medication so far — with individuals obtaining an average weight reduction of 21.6 pounds (9.8 kg) after taking the dose for a year,

In consumers, this weight loss has translated into a significant reduction of waist circumference, enhanced insulin sensitivity, and blood glucose control, in addition to positive effects on cholesterol and cholesterol levels.

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Studies affirm the potency of phentermine for weight reduction. What is more, the result is much higher when the medication is blended with topiramate.

May Be Helpful for Certain Eating Disorders

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BED is characterized by eating considerable quantities of food, often quickly and into the purpose of distress. Additionally, it is connected with a sense of losing control throughout the binge, in addition to feelings of guilt or shame afterward.

Bulimia nervosa involves the same binge-eating behavior as BED but contains tones, for example, self-induced nausea, and to compensate for the consequences of binge eating.

In little 12-week research in obese or obese people with BED, the phentermine and topiramate medication mix was associated with substantial reductions in fat, BMI, along with binge-eating episode regularity.

In a different 12-week study, individuals with BED or bulimia nervosa were randomized to receive the medication mix or a placebo.

Within 28 days, therapy with all the phentermine and topiramate combinations decreased the participants’ amount of binge-eating times from 16.2 to 4.2. The very same results weren’t found in the placebo group.

By decreasing binging episodes, the drug combination might assist the projected 40–80 percent of individuals with BED or bulimia nervosa that are obese or obese eliminate weight while enhancing mood and a feeling of control with ingestion.


The phentermine and topiramate blend was demonstrated to overweight or obese decrease binging episodes and burden from people with BED and bulimia nervosa.

Dosage and Forms

Dosages for phentermine change based on its kind and concentration.


Before 2016, the accessible doses of phentermine have been 15, 30, and 37.5 mg.

But because it is suggested that physicians prescribe the lowest effective dose, the FDA approved an 8-mg formula in 2016, which is obtained up to 3 times each day.

You should avoid taking the final dose too late daily to stop insomnia or difficulty falling or staying asleep.

Phentermine and Topiramate

Phentermine and topiramate — marketed under the brand name Qsymia — is a combination medicine used for weight reduction.

This medicine is available in several doses, varying in power from 3.75 to 15 milligrams of phentermine and 23 to 92 mg of topiramate.

After choosing the lowest dose for 14 days, your health care provider can opt to advance you to a higher dose.

The medicine ought to be discontinued in case you do not lose 5 percent of your body weight after 12 months on the highest daily dose.


The dose of phentermine differs, depending on if it is used by itself or alongside topiramate.

Side Effects and Precautions

Phentermine alone is created for short-term usage only because there aren’t any long-term studies on its security.

However, the FDA has accepted phentermine together with topiramate for long-term usage, because the dose of those two ingredients is significantly lower than the highest doses of these individual drugs.

While serious adverse effects are infrequent, research reports many side effects of the phentermine and topiramate mixture.

Fatigue The most frequently reported side effects to include.

Your health care provider will decide whether phentermine is safe and appropriate for you.


While there are many side effects related to the usage of phentermine, and it is tolerated by the majority of people. But people with specific conditions and women that are nursing or pregnant shouldn’t use phentermine.

Healthy Ways to Promote and Maintain Weight Loss

While phentermine may be highly effective weight loss aid, the only proven method to lose weight — and keep it off in the long term — is cultivating healthy lifestyle behaviors.

Without making the correct modifications, you’ll likely get back the weight you lost — and maybe more — after you stop taking phentermine.

A comprehensive lifestyle change comprises:

  • A reduced-calorie diet when you’ve got excessive fat to lose, consume 300–500 fewer calories every day. A registered dietitian can help you tailor this variety according to your tastes and goals.
  • Prioritize Spicy foods: Nutrient-dense meals — like vegetables and fruits — are comparatively low in carbs and high in nutrients, such as vitamins, fiber, and minerals.
  • Boost physical action: Nutrient-dense foods Guidelines recommend no less than 150 minutes a week of moderate aerobic workout, for example, brisk walking or jogging.
  • Behavioral plans: Behavior changes comprises routine self-monitoring of food consumption, physical activity, along with your weight, also making adjustments as necessary.

Creating these lifestyle modifications can be challenging and should not occur all at one time. It will require an investment of your own time and energy, but the result will probably be long-term weight reduction and overall health.


Lifestyle and behavioral modification will be the cornerstones of effective weight reduction and maintenance.

The Bottom Line

The combination of phentermine and topiramate seems to be much more effective and more tolerable compared to phentermine alone.

Adverse effects include dry mouth, nausea, tiredness, irritability, as well as constipation.

While phentermine may be a beneficial short-term weight reduction tool, you need to make substantial lifestyle modifications for long term achievement.

Norm makes it possible to embrace healthy habits so that you may get rid of weight and keep it off. Your schedule is customized to your objectives and exercise requirements. Just take a quick assessment and get started now.